Research found that people taking their antihypertensive medication before bed had better blood pressure control and consequently had a much lower risk of death or disease due to heart problems compared to people taking their medication in the morning.  Compared to those who took their medicine in the morning, the people who took their medicine at night had almost half the risk of dying from heart problems and almost half the risk of heart attack, stroke, heart failure, heart attack or
When researchers looked at individual heart problems saw those taking their pills at night reduce their risk of death from heart or blood vessel problems by 66%. The risk of stroke decreased by 49%. The risk of heart attack decreased by 44%. The risk of heart failure decreased by 42% and coronary revascularization by 40%.
Researchers calculated this and looked at data from 1
9,084 patients enrolled in the Hygia Project, a network of health centers in Spain. Researchers compared the results of people taking their pills at night versus those who took them when they got up in the morning. They followed these patients for more than six years. The patient's blood pressure was checked for 48 hours at least once a year.
The authors claim that there is no significant study showing that taking antihypertensive medication works best in the morning, although it is common for doctors to recommend that you take it when you wake up.
"Morning intake has been the most common recommendation from physicians based on the deceptive goal of lowering blood pressure in the morning. But the Hygia Project has previously reported that the average systolic blood pressure when a person sleeps is the most significant and independent indication of risk for cardiovascular disease, regardless of blood pressure measurements made when awake or when visiting a doctor, "author Dr. Ramon Hermida said in a statement. Hermida works with Bioengineering and Chronobiology Laboratories at the University of Vigo, Spain.
More research needs to be done to see if the results can be replicated in other ethnic groups.  "We've been waiting for this, this is a practice change study," Dr. John A. Osborne, who was not involved in the study, but is the director of cardiology at State of the Heart Cardiology in Southlake, Texas and serves as a volunteer in the American Heart Association.
Osborne said he had noticed the smaller trial conducted by this group that showed similar results and had looked at the results of this larger study. Seeing these "amazing" results results in a much larger group of people in a real world situation, "it is practice to change data."
Asked why doctors may have told their patients To take their medicine in the morning, Osborne said it may have been that doctors thought it would be easier for people to remember to take their pills in the morning or it may be because some high blood pressure drugs are diuretics.
"You probably don't want to take a pill at night that makes you stand up and pee, but after a few weeks, this gradually becomes less of a problem, so it shouldn't be a problem," Osborne said. "Especially when you see that there is such an advantage to this."
Dr. Barbara Roberts, a cardiologist and assistant clinical professor of medicine at Brown, said she applauds the researchers who did this work. "I think you're going to see doctors come to this quickly," Roberts said. "Hypertension is such a strong risk factor for cardiovascular disease, much greater than cholesterol and anything that allows us to treat this more effectively is important."
Dr. Tim Chico, who was not involved in the study, but is a professor of cardiovascular medicine and honorary consulting cardiologist at the University of Sheffield, told the Science Media Center in the UK that the results were "impressive." He said you should talk to your doctor, as with any changes in your routine, and he said further studies will be needed to confirm these results.
"But because it takes little risk to take medication at bedtime," said Chico, "there is enough evidence from this study to recommend that patients consider taking their medication at bedtime."