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UNM researchers develop vaccines that can protect against Alzheimer's



University of New Mexico researchers have developed a vaccine that can prevent Alzheimer's disease. PhD student Nicole Maphis, who is in UNM's biomedical science education, says: "We are pleased with these results, because they seem to suggest that we can use the body's own immune system to make antibodies against these intestines and that these antibodies actually bind and clearing these tau tangles. "Maphis and Kiran Bhaskar, associate professor of UNM's molecular genetics and microbiology department, found that when the vaccine was given to mice, they developed antibodies that cleared the tau protein from their brains and the response lasted several months. . Then Maphis and Bhaskar tested the animals in a battery of labyrinth-like tests. Mice that received the vaccination performed significantly better than those who did not. MRI scans showed that the vaccinated animals had less brain shrinkage, which meant that the vaccine prevented neurons from dying. Maphis says, "These results confirm that targeting tau tangles using a vaccine intervention can save memory losses and prevent neurons from dying." UNM researcher David Peabody and Bryce Chackerian created the vaccine. The two also helped to create vaccines targeting dengue virus, hepatitis B and human papillomavirus (which are present in the brains of Alzheimer's patients). In the future, Bhaskar wants to get funding to commercialize this vaccine to create an injection that can ever be tested in human patients with Alzheimer's. Baskar is optimistic that she will receive funding for the vaccine from a federal Small Business Innovation Research grant to move on with the research project. However, creating this drug can potentially cost millions of dollars and take decades.

Researchers in New Mexico have developed a vaccine that can prevent Alzheimer's disease.

PhD student Nicole Maphis, who is in UNM's biomedical science education, says: "We are happy about these concerns, because they seem to suggest that we can use the body's own immune system to make antibodies against these tangles and that these antibodies actually bind and clearing these tau tangles. "

Maphis and Kiran Bhaskar, associate professor of UNM's Department of Molecular Genetics & Microbiology, found that when the vaccine was given to mice, they developed antibodies that cleared the tau protein from their brains and the response lasted in several months.

Then, Maphis and Bhaskar tested the animals in a battery of labyrinth-like tests. Mice that received the vaccination performed significantly better than those who did not. MRI scans showed that the vaccinated animals had less brain shrinkage, which meant that the vaccine prevented neurons from dying.

Maphis says: "These results confirm that targeting of rope tangles using a vaccine intervention can save memory losses and prevent neurons from dying."

UNM researcher David Peabody and Bryce Chackerian created the vaccine. The two also helped to create vaccines targeting dengue virus, hepatitis B and human papillomavirus (which are present in the brains of Alzheimer's patients).

In the future, Bhaskar wants to get funding to commercialize this vaccine to create an injection that one day could be tested in human patients with Alzheimer's.

Bhaskar is optimistic that she will receive funding for the vaccine from a federal Small Business Innovation Research grant to go ahead with the research project.

However, creating this drug can cost millions of dollars and take decades.

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