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Cancer treatment can be hidden in the genetic code for elephants

Large mammals should be at greater risk of cancer than humans, given their bodies and life expectancy. According to research by Oxford University epidemiologist Richard Peto, cancer is less likely, although larger cells have the potential to exponentially transform into more cells. Now scientists think they know why, and they say it can be an example for humans.

Joshua Schiffman, ferocious elephants are 100 times the size of humans . They should all die of cancer and be compromised. But has fewer cancers says. Most have two copies of a gene encoding p53 (a cancer-fighting protein, which Schiffman calls "the protection of the genome"). People with Li-Fraumeni, a hereditary cancer hypersensitivity syndrome, have only one copy instead of two to encode this protein. This cell can act to repair damage or destroy a cell that is about to become cancerous. Schiffman said that people with Li-Fraumeni syndrome have a risk of developing cancer 1

00% throughout their lives. Schiffman said that the number of people only two counted as. He and senior author Carlo Maley, an evolutionary biologist at Arizona State University, put forward the theory that elephants p53 will repair cells that are cancerous or turn into cancer at a higher rate than humans.

Their results did not confirm the "data-original =" / images / editor / default / 0002/28 / 955fa2661fe04edd811765cf274e6033835ddf22.jpeg "style =" width: 788px; height: 526px; "/>

Schiffman " We looked closely at our results. What we saw surprised us, but it made sense ". The degree of repair was similar but with elephants it was the method of attacking the breakthrough differently: cell death . For the elephant Schiffman, "It is so important that we do not develop cancer, rather than follow the division of the cells and decide if they will turn into cancer, we need ultimate protection to completely get rid of the damaged cell. 19 Schiffman and his team ended on Thursday. by American Medical Association

The next step is to test these proteins in different species

  Elephants are rarely caught in cancer

Mouse cells appear to develop cancer resistance when extra copies of the p53 gene are given. In the lab, Schiffman said elephants took p53 and transmitted it to Li-Fraumeni cells to see what it was. that these genes can be cancer. a person at risk or already sick. He hopes to be able to do a clinical trial in the next three to five years.


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The study gives him a new perspective when talking to his patients. Olduğunda When I have a patient who has a syndrome in front of me and definitely will have cancer, elephants do not have cancer and we work with the zoo and circus to learn from elephants. So he says that one day you would never have cancer . He then tells the kids that he started laughing and talking about how they wanted to go to the zoo.

Source: http://blogs.discovermagazine.com/d-brief/2015/10/08/elephants-cancer-genes/#.XcZWXiTVLDd

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