Does the intestinal microbiome have brain health?
When people get older, their blood vessels naturally strengthen over time. This increases the risk of cardiovascular disease. Researchers now wanted to find out why this stiffening of the blood vessels occurs. They found that changes in gut microbiota have adverse effects on vascular health as they age.
A recent study by the University of Colorado Boulder has now found that natural changes in the intestinal microbiota with increased age adversely affect our health. The results of the study have been published in the English journal "Journal of Physiology."
Mice treated with antibiotics
This is the first study that shows that changes in intestinal microbiota can affect the negative impact of age disease. This opens up a whole new way of potentially preventing cardiovascular disease. In the study, the research group administered broad-spectrum antibiotics to young and old mice to kill the majority of bacteria that live in the intestines. Then, the health of the vascular endothelium (the interior of her inner vessel) and the stiffness of her large arteries were measured. Blood levels of inflammatory compounds, tissue-damaging free radicals, antioxidants and nitric oxide were also measured in all animals. Suppression of the Microbioma Residual Vascular Health After three to four weeks of treatment, no change in vascular health was observed in the young mice. However, in the older mice, a strong improvement was noted at all the above points. When the microbiomas of the old mice were suppressed, the vascular health of the animals was restored. This suggests that these microorganisms do something that causes vascular dysfunction. To find a possible cause, the researchers took pallet samples from another group of mice and genetically sequenced them, the comparative bowel bacteria of old mice with the young animals.
What could be identified? In mice, an increased incidence of microbes that are pro-inflammatory and previously associated with disease has been observed. In the old mice, there were significantly more proteobacteria, including salmonella and other pathogens, as well as proinflammatory desulfovibrio. In addition, blood levels of metabolites in old and young mice were measured. Old mice had three times as much TMAO (trimethylamine N-oxide) in the body, a metabolite associated with increased risk of atherosclerosis, heart attack and stroke, the authors explain in a press release.
Does our intestinal microbiota produce Change toxic substances?
It has long been known that oxidative stress and inflammation cause arteries to become ill over time. Why the arteries are affected by stress or ignition, it was not yet known. Presumably, the intestinal microbiota begins to produce toxic molecules (including TMAO) that enter the bloodstream, cause inflammation and oxidative stress and damage the tissue.
Dimethylbutanol blocks enzyme for TMAO production
Antibiotics should not be considered a kind of youth source for our cardiovascular health. It was used exclusively as an experimental agent in the study. There are too many side effects and other problems when using antibiotics on a large scale. A diet rich in probiotic foods (such as yogurt, kefir, kimchi) and prebiotic fiber can play an important role in the prevention of heart disease by promoting a healthy intestinal microbial. Researchers also examined a compound called dimethylbutanol found in some olive oils, vinegar and red wines that block the bacterial enzyme required to make TMAO. Ultimately, dimethylbutanol can be developed into a dietary supplement. (As)