New treatment for the protection of the heart?
Researchers have now identified the mechanism, which ensures that intense light provides protection for heart attacks. The light enhances a gene, which strengthens blood vessels and protects them from heart attacks.
The current study at the University of Colorado School of Medicine decides who protects intense light from heart attacks. The results of the study were published in the English-language journal "Cell Reports".
What role does the PER2 gene play?
It has been known that intense light can protect against heart attacks, but that researchers have just found the mechanism that is relevant here. They found that the accommodation of mice under intensive light conditions for a week significantly improved the protection of the heart, yet another heart attack led to a drastic deterioration of the damage to the heart tissue. The research team assumes that humans could benefit from a similar exposure strategy.
The research needed intense light to control and manipulate the function of the PER2 gene. The strengthening of this gene by light has the consequence that cardiovascular tissue for oxygen-deprived states (which are caused by a decreased oxygen flow to the heart) that protected myocardial ischemia. In addition, the researchers discovered that light increases cardiac adenosine, which plays a role in blood flow regulation. This demonstrates the need for a visual perception of light in order to benefit from the benefits of light radiation. Next, researchers investigate whether intense light has similar effects on healthy human volunteers. Intense light was exposed for 30 minutes. In this case, the volunteers were deferred to 10,000 LUX in five consecutive days. The research also led to serial blood transfusions.
The intensity of light irradiation is very important
The light therapy increased the PER2 mirror in the participants as in mice. So-called plasma triglycerides take the treatment significantly off. Overall, the therapy improved metabolism. The duration of light irradiation is apparently not as important as the intensity, researchers report. spielt. The study group pointed out that earlier studies in all US states, including sunny places like Arizona, Hawaii and California, have shown a rise in myocardial infarction during darker winter months. The study at the molecular level now indicates that an intensive light therapy is a promising strategy for the treatment or prevention of oxygen-poor conditions that myocardial ischemia. (as)
- Yoshimasa Oyama, Colleen M. Bartman, Stephanie Bonney, J. Scott Lee, Lori A. Walker et al: Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium, in Cell Reports (Inquiry: 09.08.2019), Cell Reports