Researchers have found that small bubbles in our body can potentially be used to treat cancer and can fight the disease better than chemotherapy.
Healthy cells in the body release nano-sized bubbles that transfer genetic material such as DNA and RNA to other cells. It is your DNA that stores the important information necessary for RNA to produce proteins and ensure that they act accordingly.
According to the researchers, these bubbling extracellular vesicles (EVs) can become mini-treatment transports, carrying a combination of therapeutic drugs and genes targeting cancer cells and killing them.
The study, published in the journal Molecular Cancer Therapeutics, focused on breast cancer cells in mice.
"What we have done is to improve a therapeutic strategy to deliver enzyme-producing genes that can convert certain drugs into toxic substances and target tumors," said study lead author Masamitsu Canada, assistant professor at Michigan State University.
These drugs or drugs But when they are first metabolized in the body, they are activated immediately and can work to fight everything from cancer to headaches.
Aspirin is an example of a common drug.
In this case, researchers used EVs to deliver the enzyme-producing genes that could activate a drug combination therapy of ganciclovir and CB1
This is known as a gene-targeted enzyme, drug therapy.
They found that the mini-circle DNA was 14 times more effective at delivery and even more successful in killing cancer tumors.
19659002] "Conventional chemotherapy cannot differentiate between tumors and normal tissue, so it attacks everything," Canada said.
With EVs, treatment can be targeted and because of their compatibility With the human body, this type of delivery can minimize the risk of unwanted immune responses that may come with other gene therapies.
"If EVs prove to be effective in humans, it would be an ideal platform for gene delivery and it could be used in humans sooner than we expect," Canada added.