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Substance produced by the body has the potential to treat diabetes



Brazilian scientist Luiz Osório Leiria, during a postdoctoral research at Harvard University in the United States, identified a substance produced by the body that helps control glucose levels and may be an alternative to combat diabetes. He is currently a researcher at the Institute of Biology at the State University of Campinas (Unicamp).

In an article published in the journal Cell Metabolism Leiria first describes the functions of such a substance, 12-HEPE lipid. , a type of fat produced and released by brown fat tissue. Brown fat tissue is mainly related to the body's thermal regulation through heat production. White fat tissue is the one related to obesity and its function is to accumulate fat when there is excess energy.

In research, Leiria found that obese mice treated with lipid 1

2-HEPE showed greater efficacy in reducing fat levels. blood glucose after receiving a concentrated glucose injection compared to mice that had not received lipid therapy.

"We have shown that 12-HEPE could improve glucose tolerance in obese animals, which is due to its ability [lipídio] to promote glucose uptake in adipose tissue and muscle. Increasing glucose tolerance means the ability to transport glucose to tissues after a high intake of food (with glucose) by lowering blood glucose levels, says Luiz Osório Leiria.

The researcher showed that the beneficial effect of lipid was due to the ability of 12-HEPE to promote glucose uptake in both muscle and brown adipose tissue itself.

Diabetes [19659007] The significance of the finding for a possible treatment for people with diabetes is that patients in it have high blood sugar levels and need medication to reduce these levels, Leiria identified in the research that lipid 12-HEPE had performed the function of lowering blood sugar levels in obese mice. [19659002] "It is early to say, but it can mean yes [um novo tipo de tratamento] for in type 2 diabetes that glucose intolerance occurred father, that is, a defect in the body's ability to pick up glucose after a meal occurs and that blood glucose stays elevated for a long time, "he explained.

In clinical studies with human patients By taking blood samples from thin and healthy people, as well as from obese and obese patients, it was found that the amount of 12-HEPE in the first group was higher than in the blood of obese and obese patients.

That is, research suggests the possibility of lowering these lipids in the bloodstream for obese people may in some way contribute to the increased blood sugar in these patients. The subject has not yet been tested as a treatment in humans, but the researcher says he intends to test in the future.

In in vitro tests on human fat cells, the results showed that 12-HEPE increased glucose uptake. "In humans, we know two things: lipid levels are reduced in overweight people, and when individuals take a drug (Mirabegron) that activates brown fatty tissue, lipid is released into the bloodstream," Leiria said.

A cure Already marketed in the country called Mirabegron, indicated for the treatment of a urinary dysfunction known as overactive bladder, it also has the ability to activate brown fatty tissue. Leiria's research has shown that patients treated with this drug have higher levels of 12-HEPE in the blood.


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