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Occupational exposure to disinfectants may increase COPD risk



New data published in JAMA Network Open showed that the risk of COPD was higher among nurses who regularly performed cleaning and disinfection tasks.

The researchers evaluated data from 73,262 women (mean age, 54.7 years; 96% white) who participated in Nurses & # 39; Health Study II from 2009 to 2015. Participants were still working in a care job and did not have COPD 2009 Off these women reported 22.9% weekly use of disinfectants for clean surfaces and 19% reported weekly use of disinfectants to clean medical instruments.

Based on 368,145 person-years of follow-up, 582 nurses reported having diagnosed COPD. After adjusting for age, smoking, race, ethnicity and BMI, the associated weekly use of disinfectants was analyzed only on clean surfaces (adjusted HR = 1

.38; 95% CI, 1.13-1.68) and weekly use of disinfectants to clean medical instruments (aHR = 1.31; 95% CI, 1.07-1.61) with COPD.

Remarkably, nurses who often used disinfectants – 4 to 7 days per week – had a higher risk of COPD, with an aHR of 1.43 (95% CI, 1.13-1.8; P for trend <0.001) for use of any disinfectants and an aHR of 1.37 (95% CI, 1.09-1.72; P for trend = .003) for use of disinfectants only for cleaning surfaces.

The results also indicated that high-level exposure, determined by a job-task exposure matrix, for glutaraldehyde, bleach, hydrogen peroxide, alcohol and quaternary ammonium compounds was associated with increased COPD incidence, with aHRs of 1.25 (95% CI, 1.04-1.51) to 1.36 (95% CI, 1.13-1.64).

Smoking or asthma status did not appear to significantly affect the association between this week's disinfectant and COPD, according to data.

"A great deal of evidence already proves the association between these exposures and asthma; our additional results from a association with COPD incites the need to develop exposure reduction strategies that remain compatible with infection control in health care environments, "the researchers wrote.

"Further research is needed to better establish a causal link between exposure to cleaning products and disinfectants and COPD development. Nevertheless, clinics should be aware of this new risk factor and systematically look for sources of exposure to cleaning products and disinfectants in addition to other occupational exposures in patients with COPD. ” – by Melissa Foster [19659002] Publication s : Several of the authors report that they received grants from the National Institute for Occupational Safety and Health (NIOSH) from the CDC. Another author reports that he received personal fees from Partners HealthCare System and that he is a paid consultant for a NIOSH R01 grant.

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