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Omega-3 shows protection against heart disease-related death, without risk of prostate cancer



  PICTURE

PICTURE: Should you take omega-3 pills? Or try having two for servings of omega-3 rich fish a week, as recommended by the American Heart Association? It may seem a bit cloudy …
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Credit: Intermountain Healthcare

Should you take omega-3 pills? Or try having two for servings of omega-3 rich fish a week, as recommended by the American Heart Association? It may seem a bit shady if you follow the headings on nutrition and health.

That is why researchers at the Intermountain Healthcare Heart Institute continue to investigate the potential benefits and risks of this popular supplement, especially in prostate cancer risk and heart health.

The Intermountain research team presented two new omega-3 studies at the 201

9 American Heart Association Scientific Sessions in Philadelphia on November 17, 2019.

In one study, the Intermountain research team identified 87 patients who were part of the Intermountain INSPIRE registry and had developed prostate cancer. These patients were also tested for plasma levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are two common omega-3 fatty acids.

Compared to a matched control group of 149 men, the researchers found that higher omega-3 levels were not linked to increased risk of prostate cancer.

Viet T. Le, MPAS, PA, researcher and physician assistant at the Intermountain Healthcare Heart Institute, said they conducted this study based on findings from a 2013 paper from the Journal of the National Cancer Institute that suggested a possible link between higher omega-3 plasma levels and the development of prostate cancer, one that has been discussed since its publication.

"If I recommend omega-3 for my patients to save their hearts, I want to make sure I do not put them at risk for prostate cancer, Le said." Our study found no evidence of a link between the two. "[19659005] In the second study presented at the American Heart Association Scientific Sessions in 2019, Intermountain researchers looked at 894 patients who underwent coronary angiography (a test that shows how blood flows through the arteries in the heart).

These patients had no prior history of heart attack. or coronary artery disease, but at their first angiogram, about 40% of these patients had severe disease and about 10% had three-vessel disease, Le said.

Researchers also measured the patient's plasma levels of omega-3 metabolites, including DHA and EPA. patients were then followed to see who had subsequent heart attack, stroke, heart failure or who died.

Researchers found that patients who had higher rates of ome Ga-3 metabolites were at lower risk for them following up on adverse effects whether they had a serious illness or not on their initial angiogram.

"This study is important because we looked at how omega-3 helps patients who have already developed disease, and its effects on survival – both to get to the first angiography to be diagnosed (against having a heart attack or worse in the past) also knowing that they have heart disease) and beyond, "Le said.

"Although an apparent association between higher plasma omega-3 levels and the results of severe heart disease on initial angiogram may raise alarms that omega-3 is of no use, they lived to see a doctor and get the diagnosis, "Smile Added. "And we saw a link between higher levels of omega-3s and their survival rate thereafter."

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Other members of the research team include: Kirk U. Knowlton, Raymond O. McCubrey, Stacey Knight, Mohit Jain, Jeramie Watrous, Mahan Najhawan, Khoi Dao, Tami L. Bair, Benjamin D. Horne, Joseph B. Muhlestein, Donald L. Lappe, Madisyn Taylor, John F. Carlquist and Jeffrey L. Anderson.

This research was sponsored by the Intermountain Research and Medical Foundation and the Dell Loy Hansen Foundation, Inc.

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