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Parkinson’s disease would start in the nose



THE ESSENTIAL

  • One of the first signs of Parkinson’s disease is odor loss.
  • Some researchers believe that odor dysfunction may be linked to the onset of the disease.

Posted in Brain Pathology, A new study strengthens the hypothesis that Parkinson’s disease begins in the nose. “Parkinson’s disease is a devastating neurodegenerative disorder, recalls Randy Blakely, CEO of FAU’s I-BRAIN. There is currently no cure for the disease, and drugs that delay its development have significant side effects. “ he adds.

smell Loss

Odor loss is one of the first signs of Parkinson̵

7;s disease and can even occur years before the tremors and reduced motor function. Some researchers believe that odor dysfunction may be linked to the onset of the disease.

By working with mice, Dr. Ning Quan and his team showed that inflammation in the lining of the nose then triggers inflammation in brain molecules involved in Parkinson’s disease. Inhaling too many environmental toxins from bacteria, viruses, mold, dust, pollen or chemicals can trigger Parkinson’s disease.

“Data from our study show that sequential inflammatory activation of the olfactory mucosa triggers subsequent expression of inflammatory molecules in the brain and spreads inflammation,” summarizes Dr. Ning Quan.

Motor and non-motor symptoms

Remember in this context that a study by Public Health France reported two years ago that farmers and residents of cultivated areas have a 10% higher risk in addition to getting Parkinson’s disease, especially due to pesticides.

Parkinson’s disease is the second most common neurological disease after Alzheimer’s disease. It is a pathology characterized by motor and non-motor symptoms. As it progresses, patients will have an increased risk of addiction, especially due to motor complications (dyskinesias, fluctuations, falls) and cognitive (cognitive decline, hallucinations, dementia).


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