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New molecule can inhibit Alzheimer’s-like memory loss

With information from: Science
Latin News Agency for Medicine and Public Health

Research on a drug has shown great effectiveness in reducing the aging of brain cells

A study on physetin, a chemical component found in fruits and vegetables, can help brain cells recover and prevent diseases such as Alzheimer’s, the drug has been effective in mice, the research team has synthesized variants of this component and CMS121 proved to be very effective in improve memory in animals and prevent degeneration of brain cells.

“This was a more rigorous test of how well this compound works in a therapeutic environment than our previous studies on it,” says Pamela Maher, a senior researcher in the laboratory of Professor David Schubert de Salk.

Study design

The research team used CMS1

21 in mice suffering from Alzheimer’s, injected daily doses starting from the first months of the animals, corresponding to the average age of the people, they received this dose from the learning degeneration and memory, to adapt the process through which a patient with this condition must pass.

At the end of the three months of treatment, the research body was responsible for performing appropriate behavioral and cognitive tests on the animals as follows: they compared the animals that had undergone CMS121 and those who did not have a brain complication, in addition to those who suffered and were not injected. compared with memory and behavioral tests, the injected mice responded in parallel to the healthy ones, while those who did not receive the drug had slower dexterity.

The specialists noted that at the cerebral level, lipids were different between the three animals, as the patients had differences between the healthy and the treated animals, which led to a clear conclusion and identification, that lipid peroxidation was very high in the diseased samples. Compared to the other two, peroxidation is a breakdown of lipids that produce radical molecules that can cause cell damage.

Study conclusions

CMS121 was shown to achieve a reduction in the levels of a lipid-producing molecule, called fatty acid synthetase (FASN), while reducing the increase in lipid peroxidation.

A study conducted by the researchers on the patients who died of Alzheimer’s heart decrypted that the concentration of FASN was very high, suggesting a progress and a pharmacological study that can regulate these increases in FASN lipids at the brain level.

“It has been a big battle in the field right now to find goals to follow. So impartial to identify a new target like this is really exciting and opens many doors, Maher adds

It is important to remember that the various studies and studies are very important to be able to treat the diseases that are considered irreparable, this is a big step forward so that the patients who have Alzheimer’s symptoms can be treated and avoid the disease that damages a proportion of it. long-lived population.

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