A key fund that finances the fight against AIDS, tuberculosis and malaria seeks new investments worth SEK 1
French President Emmanuel Macron launches the latest round to complement the global fund in Paris.
It's called "a crucial moment".
The fund says that progress has slowed down due to the political commitment and increased insecticide and drug resistance.
Raising the target amount can help save 16 million lives, it is claimed as well as halving the death rate from these three significant diseases.
The £ 11 billion ($ 14 billion) would be spent on drugs that treat and prevent HIV transmission, TB drugs and mosquito nets to protect against malaria.
"Progress has stalled"
The Fund's Managing Director Peter Sands told BBC News: "We have made extraordinary progress in reducing these deaths – but it has progressed.
" Comes into this the post, I really suffered from the strength of political support for the global fund in many different capitals.
"I am not at all self-righteous over the challenge of raising the money we need – and obviously the geopolitical environment is complicated.
" But we are convinced that we have a strong investment case – and a demonstrable level to give effect , "he said.
The Global Fund has generally been considered a success story of how it collects and uses global health funds from governments and other donors.
But the fall in investment warns of deficiencies in funding and it says this could threaten the third Sustainable Development Goal – an internationally agreed objective to end disease epidemics, and create viable health systems for all people.
"New infectious threats"
Malaria cases are increasing, after years of steady decline. Two-thirds of all malaria deaths affect children under five.
Although antiretroviral drugs have stopped millions of people dying from AIDS, the huge increase in Africa's young population poses a threat to more new infections than the height of the epidemic at the beginning of this century.
Tuberculosis kills more people than any other infectious disease – and drug-resistant cases account for one third of all global deaths due to antimicrobial resistance.
Director General of the World Health Organization Dr. Tedros Adhanom Ghebreyesus praised Global Fund's "truly impressive impact on growth" during its 17 years.