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Evolution Could Explain Why Staying Slim Is Tough

TUESDAY, July 16, 2019 (HealthDay News) – It's not easy to maintain a healthy weight.

Why would the body seem to encourage obesity?

New research suggests the answer lies in human evolution, with an anti-starvation mechanism that primes the body to large fat

The key to this mechanism is a protein dubbed "RAGE," according to New York University (NYU) scientists working with mice. They believe RAGE evolved to help keep ancient humans from starving when food was scarce.

But today, in times of plenty, there is a glitch at work: RAGE is produced to combat the cellular stress caused by overeating .

And so it switches off the body's ability to burn fat. The result: fat becomes easy to accumulate, but tough to shed.

Still, there is a silver lining to all of this, the NYU team said, because the research might lead to anti-obesity drugs.

"Our thinking is that RAGE is targetable. When we put mice with no RAGE expression at all on a high fat diet, they ate the food but were not becoming obese, "explained study author Dr. Ann Marie Schmidt, from the NYU School of Medicine.

And a lack of RAGE appeared to be safe, at least for mice. "When you totally delete RAGE in mice, they have normal reproduction and no problems with cognition," she said.

The researchers hope that RAGE seems to be active just during times of metabolic stress instead of during everyday functions, taking it away won't create problems.

But don't pinpoint your hopes on a RAGE deleting drug just yet.

Schmidt was quick to note that any such drug is a long way off because the research is currently in mice. Findings from animal studies don't always translate to humans.

Still, Schmidt said the potential is exciting.

In addition to limiting the body's ability to burn fat, RAGE may also contribute to inflammation throughout the body. So, along with taming obesity, it is possible that removing the RAGE protein might help with some of the inflammatory consequences of obesity, such as diabetes, cancer, hardening of the arteries and Alzheimer's disease, according to the researchers.

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