Experts talk about a human peptide (a compound of organic origin that is formed by combining several amino acids) called bradykinin. It usually helps regulate blood pressure. However, in the case of infected people, the virus seems to increase the production of this substance, which can cause a subsequent storm in the body.
“Such a storm could explain why women, for example, suffer from a milder form of the disease compared to men,” quoted the NewScientist expert from the University of Michigan.
In one study, a team of American researchers studied gene expression (the process by which genetic information is stored in a gene and usually transformed into a protein structure) in lung fluid samples from infected patients, compared to samples from a group of people who covered 1
It was in infected patients that they discovered evidence of overexpression of genes responsible for increased bradykinin production. Gene expression was reduced in uninfected humans.
Bradykinin should dilate blood vessels and increase their permeability. However, high amounts can cause it to escape into various parts of the body, such as the lungs. According to Canadian expert Joe Penninger, these hypotheses may be the key.
However, there are drugs to regulate bradykinin and are currently being tested by experts as a potential drug against coronavirus. In the Netherlands, therefore, doctors began testing Icatibant on nine infected patients in July.