Home / Health / Curious robot spray-in-a-pill completes successful human trial / Boing Boing

Curious robot spray-in-a-pill completes successful human trial / Boing Boing

RaniPill is another syringe that you can swallow to deliver drugs to the blood from the inside. It is triggered by an interesting and complex mechanism with a chemical reaction that inflates a small polymer balloon to push the needle into the intestinal wall. Rani Therapeutics just completed a successful test for 20 people using a pill that pushes up substances. From IEEE Spectrum:

RaniPill works from the outside, consisting of a special coating that protects the pill from the stomach's acid juices. Then, when the pill is pressed into the intestines and the pH levels rise to about 6.5, the coating dissolves to reveal a deflated biocompatible polymer balloon.

When exposed to the intestinal environment, a small nip of sugar is dissolved within the balloon, which causes two chemicals to be captured on either side of the nip point to mix and produce carbon dioxide. That gas inflates the balloon and the pressure in the inflation balloon presses a dissolvable microparticle filled with an optional drug into the intestinal wall. Human intestines lack sharp pain receptors, so the microscope is painless.

However, the intestinal wall has lots of blood vessels, so the drug is rapidly absorbed into the blood, according to the company's animal studies. The needle itself dissolves …

Participants passed the balloon's remains within 1

-4 days.

(founder Mir) Imran calls the device a robot but it has no electrical parts and no metal. "Although it has no brains and no electronics, it [works through] interacts with material science and body chemistry," says Imran. "It performs a single mechanical function autonomously."

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David Pescovitz

David Pescovitz is Boing Boing's co-editor. On Instagram he is @pesco.


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